Recently several studies have explored the realization of autonomous control in production and logistic operations. In doing so, it has been tried to transmit the merit of decision-making from central controllers with offline decisions to decentralized controllers with local and real-time decision makings. However, this mission has still some drawbacks in practice. Lack of global optimization is one of them, i.e., the lost chain between the autonomous decentralized decisions at operational level and the centralized mathematical optimization with offline manner at tactical and strategic levels. This distinction can be reasonably solved by considering fuzzy parameters in mathematical programming to meet the required tolerances for autonomous objects at operational level. This claim is recommended and partially experimented in this paper. An assembly scenario is modeled by a discrete-event simulation, in which autonomous pallets carry products throughout the system. This scenario is optimized with regard to its objectives in a simulation, while fuzzy parameters in optimization programming can consider autonomous decisions done at operational level.